Lionel Messi scored in the reverse fixture in Portugal
Messi, 35, scored in the reverse fixture in Portugal last week before being withdrawn late on.
The Argentina forward also missed Saturday's Ligue 1 draw against Reims in which PSG failed to score in the league for the first time this season.
PSG top Group H on seven points, level with Benfica, with Juventus third.
Presnel Kimpembe, Nuno Mendes and Renato Sanches are also set to miss the fixture for the hosts at Parc des Princes.
-- Courtesy of BBC Sport