Manchester United beat Newcastle 2-0 in last season's final at Wembley
West Ham host Arsenal, Bournemouth are at home to Liverpool and Everton host Sean Dyche's old club Burnley in three more all-Premier League ties.
Fulham visit Championship side Ipswich and Chelsea host Blackburn.
At least two English Football League (EFL) sides will be in the quarter-finals, with Mansfield at home to Port Vale and Exeter playing Middlesbrough.
The fourth-round ties will take place in the week commencing 30 October.
Mansfield v Port Vale
Ipswich v Fulham
Manchester United v Newcastle
Bournemouth v Liverpool
Chelsea v Blackburn
West Ham v Arsenal
Everton v Burnley
Exeter v Middlesbrough
-- Courtesy of BBC Sport